View Shopping Cart - You currently have items in your shopping cart that cost a total of:

North America Orders

8 oz Bottle - $39.00	4 oz Bottle - $25.00
Qty	Qty

International Orders

Aqua-E is available only in the 4 oz. bottle outside North America. 
With international shipping and handling, the total cost is $40.00 (US Dollars). 
You can also order by contacting our international office.

4 oz Bottle - International - $40.00
Qty

Aqua-E Advantages

Vitamin E Malabsorption: Common, Extremely Serious and Preventable
by Andreas M. Papas, Ph.D.

It may be hard to believe that in the midst of an abundance of food and a plethora of supplements, many people would develop clinical vitamin E deficiency. A dramatic example is cholestasis, a condition in which excretion of the bile is stopped. Cholestatic children develop very serious and often fatal degenerative neurological diseases due to malabsorption of vitamin E. While serious cholestasis is rare, many other common diseases and physiological conditions cause varying degrees of malabsorption with subclinical deficiency. Unfortunately, vitamin E deficiency may go undetected for decades but the cumulative damage to muscle and nerves is debilitating and irreversible.

The Benefits of Aqua-E

• Aqua-E is the first dietary supplement that supplies the complete vitamin E family of tocopherols plus tocotrienols in a micellar, water-soluble format that is ready for absorption.
• Aqua-E forms micelles which enable absorption of lipophilic vitamin E in the body, even when the liver, pancreas and the digestive system do not function normally.
• Aqua-E is formulated with TPGS (d-alpha-tocopheryl polyethylene glycol 1000 succinate) to maximize absorption.
• Aqua-E is odorless and has a neutral taste. It mixes easily with most beverages and water. Dosing can be adjusted to meet the needs of children and those with special needs.
• Aqua-E is casein free & gluten free (CF/GF) and is free of animal products, yeast, wheat, added colors or flavors, sweeteners and salt. It is suitable for vegetarians.
• Aqua-E is produced under cGMP, the highest standard of manufacturing quality.
  

Who should take Aqua-E®

Aqua-E is suitable for use by vegetarians and children or adults that have difficulty swallowing pills.

Many medical conditions can cause malabsorption of fat-soluble vitamins and nutrients. Aqua-E® may aid in enhancing absorption of vitamin E in:

 Liver and Pancreatic Insufficiency

• Cholestasis
• Cystic fibrosis
• Chronic pancreatitis
• Other liver diseases (including hepatitis)

Gastrointestinal Diseases

• Inflammatory bowel disease
• Short bowel syndrome
• Infectious diseases of the gut (HIV/AIDS and others)
• Irritable bowel syndrome
• Bariatric surgery
• Celiac disease

Defects in the Transport of Vitamin E

• Abetalipoproteinemia
• Ataxia with vitamin E deficiency, or familial isolated vitamin E deficiency
• Friedreich ataxia

Aqua-E is also a convenient vitamin E supplement for conditions which may not be directly related to malabsorption. These may include people who have difficulty swallowing softgels due to their age or disease conditions and also conditions that may cause diarrhea and/or loss of appetite.

Absorption of Vitamin E: Oil and Water Do Not Mix, or Do They?

We are water-based organisms - water makes up more than half of our weight. The blood, the lifeline that carries the nutrients and nourishes all our tissues is water-based. Vitamin E, however, is fat-soluble. Oil and water do not mix. The body has to overcome this problem and micelles are the body's solution. The fat material is put into these unique tiny spheres with a water-loving (hydrophilic) outer layer and is ferried from the gut across the intestinal wall into the blood stream.

To make micelles, two major components are absolutely required.

• Bile - a yellow-green liquid produced in the liver and secreted into the gut. The bile helps emulsify the fat in our diet and provides components of the outer layer of the micelles.
  
  
• Pancreatic juice, a secretion delivered into the upper part of the small intestine (duodenum), where it aids digestion.

In the blood stream vitamin E is transported by lipoproteins, the vehicles that transport lipid materials in our body. These are minute spheres with a water friendly outer layer, which allows them to circulate freely in the blood. They carry vitamin E and other lipids in their lipophilic interior.

Which Conditions Cause Malabsorption?

A large number of diseases and physiological conditions may cause poor absorption of vitamin E.

1. Fat malabsorption due to liver and pancreatic insufficiency. Because the bile and the pancreatic juices are critical for absorption of vitamin E, any condition that compromises the function of the liver and pancreas can cause malabsorption.

These include:

• Cholestasis, a condition in which excretion of the bile is stopped or reduced. Cholestasis may be caused by inherited genetic defects and diseases and injury of the liver. Liver diseases such as hepatitis, alcoholic hepatitis and damage or inflammation of the liver from the use of powerful medicines or chemotherapy can affect the production of bile.
  
• Cystic fibrosis, a genetic disease in which the secretion of the pancreatic juice is blocked by thick mucous. Liver function and secretion of the bile may also be affected.
  
• Steattorhea, the inability to absorb fat, causes serious vitamin E deficiency. Steattorhea is associated with other conditions causing malabsorption such as cystic fibrosis, pancreatitis and is synonymous with celiac crisis, celiac rickets, celiac sprue, Gee disease, Gee-Herter disease, gluten enteropathy, idiopathic steatorrhea, nontropical sprue and wheat-sensitive enteropathy.

2. Malabsorption due to inflammation and surgical removal of part of the gut, infection, disturbance of its flora and diarrhea.

These include:

• Inflammatory bowel disease (IBD) includes diseases that cause inflammation in the intestines such as Crohn's and ulcerative colitis.
  
• Short bowel syndrome is the result of half or more of the small intestine being removed primarily in order to treat Crohn's disease.
  
• HIV is associated with fungal and other infections of the small intestine, which cause poor absorption of the nutrients particularly the fat-soluble ones. Other infectious diseases of the gut may cause malabsorption.
  
• Irritable Bowel Syndrome (IBS; also known as spastic colon or mucous colitis) can cause diarrhea and malabsorption.
  
• Bariatric surgery to treat obesity is often associated with nutrient deficiency proportional to the length of absorptive area.
  

3. Defects in the transport of vitamin E in the body have a serious indirect effect on absorption. These, mostly genetic defects, include:

• Abetalipoproteinemia is a rare inherited disease which prevents the formation of normal chylomicrons and very-low density lipoproteins (VLDL) which are essential for the transport of vitamin E. Patients with abetaliproteinemia 'absorb' vitamin E but most of the vitamin E never goes past the gut wall because the patients cannot produce these special vehicles which carry vitamin E.
  
  
• Ataxia with vitamin E deficiency, or familial isolated vitamin E deficiency, is an extremely rare genetic disease with symptoms very similar to those of another very rare disease called Friedreich ataxia. This genetic disease prevents the transfer of absorbed vitamin E from the liver to the blood and the tissues.
  

4. Aging. Aging is known to contribute to significant vitamin E deficiencies which result from diminished digestion and absorption capabilities and increased needs. It is estimated that over 50% of elderly may have suboptimal vitamin E status. Such deficiencies may be aggravated by chronic disease conditions and medications, which affect liver and other functions.

Overcoming Vitamin E Malabsorption: The Aqua-E Advantage

Aqua-E supplies the complete vitamin E family of tocopherols plus tocotrienols in a patented water-soluble formulation that overcomes malabsorption. It is particularly rich in the natural unesterified gamma tocopherol and tocotrienols, which are of particular interest to malabsorbers because of the increased oxidative stress. Each teaspoon (5 ml) supplies 100 IU plus 59 mg of gamma tocopherol for a total of 150 mg of total tocopherols. In addition, it supplies 9 mg of tocotrienols.

This proprietary formulation contains lipoprotein like microspheres which function in the same manner as micelles. In addition, after passing the gut wall these lipoproteins like micro spheres may help deliver vitamin E to the tissues even in the absence of a healthy lipoprotein transport system (for example in abetalipoproteinemia).

Aqua-E is odorless and has neutral taste. It mixes easily with most beverages and water. Dosing may be easily adjusted to meet specific needs. It is particularly suitable for people that have difficulty swallowing capsules and for vegetarians.

 

Supporting Data

Data from a clinical study with cystic fibrosis patients presented at the 2005 North American Society for Pediatric Gastroenterology, Hepatology and Nutrition show that Aqua-E produced a marked and statistically significant increase in the absorption of the gamma-tocopherol form of vitamin E in malabsorbing cystic fibrosis patients as compared to an oil-based softgel formulation. Aqua-E produces an increase in blood levels (AUC-area under the curve) of the tocopherols that ranged from 2 to 4 times higher than an equal amount of the oil-based vitamin E.

Papas K, Kalbfleisch J, Mohon R. Bioavailability of a novel, water-soluble vitamin E formulation in malabsorbing patients. Dig Dis Sci. 2007 Feb;52(2):347-52.

Detailed Product Information

Aqua-E Comparison Chart

Supplement Facts Serving Size: 10ml Servings per 8oz bottle: 24	Amount per serving	Daily Value (%)	Amount per 1.0 ml
IU from d-alpha-Tocopherol	200	667%	20
d-gamma-Tocopherol, mg	117	*	12
d-beta plus d-delta-Tocopherol, mg	42	*	4
Total tocopherols, mg	296	*	30
Total tocotrienols, mg	17	*	2
Total tocopherols plus tocotrienols, mg	313	*	32
*= Not established

 

Other ingredients: Water, natural linoleic acid, potassium sorbate.

Free of: animal products, yeast, wheat, added colors or flavors, sweeteners, Gluten, Casein (GF/CF) and salt

Dosage

100 IU	=	5 ml	=	1 teaspoon Aqua-E
200 IU	=	10 ml	=	2 teaspoons Aqua-E
400 IU	=	20 ml	=	4 teaspoons Aqua-E

 

Directions for Use: Aqua-E can be taken directly or mixed with your favorite beverage. Aqua-E may be taken at any time in a single dose or as directed by your healthcare provider. Refrigerate after opening and shake well before each use. Please consult your healthcare provider concerning dosing recommendations.

FAQs - Ordering

• How do I order Aqua-E?
• How do I order online?
• Shopping
• Checkout
• Log in / Registration
• Passwords
• Shipping
• Shipping Method
• Credit Card Information
• Submitting Your Order
• What form of payment do you accept?
• What about international orders?
• Do I have to pay sales tax on Aqua-E?
• Do you offer wholesale discounts?

How do I order Aqua-E?

Online from this site (Click ORDER NOW above)

E-mail:
email@yasoo.com

Phone:
1-888-469-2766        (toll-free USA)
1-423-926-3490        (USA and International)

Fax:
1-423-926-3586

Mail:
Yasoo Health Inc.
P.O. Box 3608
Johnson City, TN 37602-3608

For the best service, we strongly recommend ordering online. We use industry standard encryption and the Verisign Payflow System to protect your credit card and personal information.

How do I order online?

Shopping
When you click on the order button for a product you will activate the shopping cart. You can see your shopping cart including sales tax and continue shopping ("Continue Shopping" button) or checkout ("Proceed to Checkout" button). Your shopping cart will remain intact if you continue shopping and you can add / subtract items or change the quantity of a product at any time. If you change the quantity of an item click the "Update Total" button.

Checkout
When you are ready to checkout click the "Proceed to Checkout" button.

Log in/Registration
Returning customers can sign in and new customers should fill out a brief registration which includes your email address (for confirmation of you order) and password for easy reordering. This registration process allows our repeat customers the ease of not having to retype any of their personal information. You can also choose whether or not you want to store your credit card information.

What if I forget my password?
If you forget your password and the password hint that you provided is not helpful, please contact customer service at 1-888-469-2766 or e-mail email@yasoo.com.

Shipping
If you are a repeat customer your shipping information is already in the appropriate fields. You can edit it or continue to payment. New customers should enter their shipping and if different, their billing information.

Shipping Method
You can choose your preferred method of shipping. Orders are usually shipped by DHL or UPS. Please select the FAQs - Shipping tab above for more details and prices.

Credit Card Information
New customers must provide credit card payment information. Repeat customers can choose whether to have this information stored on our secure servers or re-enter it each time they make a purchase.

Submitting Your Order                                                                
Customers then submit their order by pressing the Submit Order button. A confirmation email will be sent to your email address.

What form of payment do you accept?

We accept:
VISA, MasterCard and American Express credit cards for all ordering methods, and money orders and cashier's checks via mail.

What about international orders?

We welcome international customers and will work with you for the best service.
Regulations governing nutritional supplements and customs policies vary widely from country to country. Please confirm that your country allows the import of nutritional supplements. You may be subject to import duties and taxes, which are levied once the package reaches your country. Yasoo Health is not responsible for any additional charges. Customs forms for all international packages list the content and value of your order's contents. If the order is a gift, the package is marked "Gift" but the cost of the items is still stated on the customs form.

Do I have to pay sales tax on Aqua-E?

We are required by law to add sales tax of 9.75% to orders shipped to Tennessee residents. No sales tax will be added to other orders.

Do you offer wholesale discounts?

Pharmacies and health food stores are welcome to call us at 1-888-469-2766 for our wholesale prices and terms.

FAQs - Shipping

United States

We ship by different methods depending on the weight of your shipment.  Please call customer service to arrange for alternate shipping services.

United States Shipping Rates
Ground Preferred	3 to 5 business days	$9.95 per shipment for 1 - 12 bottles $16.95 per shipment of 13 - 24 bottles
Next Day Preferred	1 to 2 business days	Contact customer service for shipping prices

 

International

We ship via DHL,UPS and USPS Global Express Mail.  Shipping prices vary depending on location and weight and additional charges may apply.  Please call customer service to arrange alternate shipping. 

References

Munoz SJ, Heubi JE, et al. Vitamin E deficiency in primary biliary cirrhosis: gastrointestinal malabsorption, frequency and relationship to other lipid-soluble vitamins. Hepatology. 1989;9:525-31.

Feranchak AP, Sontag MK, et al. Prospective, long-term study of fat-soluble vitamin status in children with cystic fibrosis identified by newborn screen. J Pediatr. 1999;135:601-10.

Bousvaros A, Zurakowski D, et al. Vitamins A and E serum levels in children and young adults with inflammatory bowel disease: effect of disease activity. J Pediatr Gastroenterol Nutr. 1998;26:129-35.

Curran FJ, Sattar N, et al. Relationship of carotenoid and vitamins A and E with the acute inflammatory response in acute pancreatitis. Br J Surg. 2000;87:301-5.

Drake WM, Winter TA, et al. Small bowel intussusception and brown bowel syndrome in association with severe malnutrition. Am J Gastroenterol. 1996;91:1450-2. Review.

Slater GH, Ren CJ, et al. Serum fat-soluble vitamin deficiency and abnormal calcium metabolism after malabsorptive bariatric surgery. J Gastrointest Surg. 2004; 8:48 -55.

Traber MG, Sokol RJ, et al. Impaired ability of patients with familial isolated vitamin E deficiency to incorporate alpha-tocopherol into lipoproteins secreted by the liver.J Clin Invest. 1990; 85: 397-407

Traber MG, Schiano TD, et al. Efficacy of water soluble vitamin E in the treatment of vitamin E malabsorption in the short bowel syndrome. Am. J. Clin. Nutr. 1994;59:1270-1274.

Sokol RJ, Butler-Simon N, et al. Multicenter trial of d-a-tocopheryl polyethylene glycol 1000 succinate for treatment of vitamin E deficiency in children with chronic cholestasis. Gastroenterology 1993;104:1727-1735.

Fletcher RH, Fairfield KM. Vitamins for chronic disease prevention in adults: clinical applications. JAMA. 2002;287:3116-26.

Papas AM. Vitamin E: Tocopherols and Tocotrienols. In Antioxidant Status, Diet, Nutrition and Health (Papas AM, ed) CRC Press, Boca Raton, 1998

Traber MG, Kayden HJ, et al. Absorption of water-miscible forms of vitamin E in a patient with cholestasis and in thoracic duct-cannulated rats. Am J Clin Nutr. 1986;44:914-23